The University of California, Sacramento is researching how omega-3 fatty acids may help heal a broken heart. New research in The FASEB Journal suggests that compounds derived from polyunsaturated fatty acids have protective properties that reduce inflammation in acutely injured blood vessels in the heart.
Procedures like angioplasty, stenting and bypass surgery may save lives. But they also cause excessive inflammation and scarring, which ultimately can lead to permanent disability and even death. One holistic natural alternative is omega-3 fatty acids, such as fish or krill oil.
A new research report appearing in Federation of American Societies for Experimental Biology journal (The FASEB Journal,) shows that naturally derived compounds from polyunsaturated fatty acids (omega-3s) may reduce the inflammation associated with these procedures to help arteries more fully and completely heal. Taking fish or krill oil usually is preferred by individuals rather than bypass surgery or stenting, if not really needed to live. And for those who’ve had the bypass surgery or stenting, a big fear is that within a year or so, the arteries will fill up again with calcium because of genetic predisposition and/or diet.
You can read the abstract of the original study, “D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury.” The study and its abstract are published in the June 2013 issue of The FASEB Journal. Authors are Takuya Miyahara, Sara Runge, Anuran Chatterjee, Mian Chen, Giorgio Mottola, Jonathan M. Fitzgerald, Charles N. Serhan, and Michael S. Conte.
Dr. Conte is a researcher involved in the work from Division of Vascular and Endovascular Surgery and the Heart and Vascular Center at the University of California, in San Francisco, CA. “Our study suggests that biologically active, naturally occurring compounds derived from omega-3 PUFAs reduce inflammation and improve the healing of blood vessels after injury,” explains Michael S. Conte, M.D., in the May 30, 2013 news release, Omega-3 fatty acids may help heal a broken heart. “They suggest a new opportunity to improve the long-term results of cardiovascular procedures such as bypass surgery and angioplasty by the therapeutic application of this class of agents or their dietary precursors.”
Dr. Conte and colleagues studied the effects of compounds such as resolvin: The potency of these compounds corresponds to concentrations that have been measured in the blood of human subjects taking high dose fish oil supplements for short periods of time
To make this discovery, Conte and colleagues studied the effects of the compounds (resolvin or RvD) first in cultured vascular cells taken from patients who had undergone bypass operations, and then in rabbits who were treated with a balloon angioplasty procedure in the arteries of the hind limb. In the human cells, treatment with RvD dramatically reduced features that are associated with the typical vascular injury response—inflammation, cell migration, and cell growth in vascular smooth muscle cells.
The potency of these compounds corresponds to concentrations that have been measured in the blood of human subjects taking high dose fish oil supplements for short periods of time. In rabbits, researchers treated the artery with RvD at the time of the balloon angioplasty procedure by infusing the drug directly into the vessel, and found that this one-time treatment reduced inflammation and subsequent scarring of the vessel after one month.
“If successful in further studies, this finding could be a huge benefit to patients undergoing these procedures,” says Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, according to the news release. “What’s even better, is that these potentially lifesaving compounds are already available in any fish market or grocery store.”